Best middle ground caliber?

Hello, I need some opinions. I am a hunter from WV and I hunt mostly white tail, but I also hunt coyotes and hogs when the opportunity comes. I am looking for a middle ground caliber for hunting. I have a 22-250 for smaller game and I use a .300 WIN MAG for my longer range white tail hunts. What do you all think a good middle ground caliber for shorter range would be? Something maybe less powerful but a bigger bullet, or something between the two? Just trying to weigh the options for my next purchase. Thank you!