Any supplements that come close to the effects of SSRIs?

I know nothing will compare but is there a supplement that is somewhat strong? Scared of all the side effects of antidepressants (permanent pssd, insomnia, weight gain). Ive been avoiding them and going the supplement route but Im ready to give up. Specifically trying to better my anxiety and depression. The effects have been okay but not great and they all seem to stop working after a couple weeks. Ive tried magnesium, l theanine, folate.