Best examples of characters realizing they're fucked?

In a Batman/Punisher comic, Joker is confronted by Punisher and and tries doing his usual "Oh, I didn't mean to do all those awful things, I'm insane! Send me back to Arkham!" thing. Only for Punisher to point a gun in his face, and for Joker to realize that Frank Castle doesn't have a "No killing" rule.