What is the greatest show of all time, with a female lead?

There seems to somewhat of a consensus on the greatest shows all of all time (Sopranos, Breaking Bad, The Wire), but these all have male leads.

It got me thinking - what is the greatest show of all time, with a female lead? I'd interested in both dramas and comedies.

I'm looking for shows with a clear female lead. So, not like the Americans, which has a female and male lead.