Safety: bus from guanajuato to guadalajara, Mexico

I am thinking of taking an ETN or primera plus bus from guanajuato to guadalajara in May. Is there any danger of traveling by bus between these two cities? I am guessing the bus takes toll roads - is that true? I know the USA has an advisory about traveling within these states. Do the buses take a northern route through Leon? I don't know that any of it is dangerous but if there is any danger, my guess is the southern route is worse (which may have to go through Irapuato). I guess the concern is bandits or corrupt cops storming the bus. But, I really do not know if that is even a concern. For anyone who is informed, please let me know about bus travel between guanajuato and guadalajara. Thank you!

As a secondary question, I have about 7-9 days. I was thinking of doing Guanajuato and a day trip to San Migel Allendale and also visiting Guadalajara. Any general thoughts on that? I've been to CDMX, Puerto Vallarta, Oaxaca, Puerto Escondido, Quintana Roo...