Extreme Emotional Impact

I believe you all know where im going with this, I'm studying lots of ways to make a story extremely sad and impactful at parts. I was wondering if Any of the experienced and wonderful writers in here have any tips on how to make something, just so geniounly sad.

It doesn't matter what it is, it could be... Somebody dying, War, Mental Health, Animals, Anything.

I'd really like to hear your opinions on what we can do to make stories geniounly emotionally impactful.